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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD6
All Species:
21.52
Human Site:
S379
Identified Species:
39.44
UniProt:
O43541
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43541
NP_001136333.1
496
53497
S379
N
L
E
Q
R
S
E
S
V
R
R
T
R
S
K
Chimpanzee
Pan troglodytes
XP_523105
496
53474
S379
N
L
E
Q
R
S
E
S
V
R
R
T
R
S
K
Rhesus Macaque
Macaca mulatta
XP_001104638
454
49165
S337
N
L
E
Q
R
S
E
S
V
R
R
T
R
S
K
Dog
Lupus familis
XP_544737
499
53465
S380
N
L
E
P
R
S
E
S
V
R
R
T
R
S
K
Cat
Felis silvestris
Mouse
Mus musculus
O35182
495
53696
S380
N
L
E
Q
R
S
E
S
V
R
R
T
R
S
K
Rat
Rattus norvegicus
O88406
426
46439
I317
V
Q
K
V
R
S
K
I
G
C
G
I
Q
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516238
280
31765
Y172
R
T
R
S
K
I
G
Y
G
I
F
L
S
K
E
Chicken
Gallus gallus
Q9W734
431
47806
T317
R
S
E
T
V
R
R
T
R
S
K
I
G
Y
G
Frog
Xenopus laevis
NP_001091249
352
38824
G244
A
R
T
R
G
K
I
G
L
G
I
V
L
S
R
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
T325
S
N
V
N
R
N
A
T
V
E
M
T
R
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
C337
T
G
E
V
Y
A
E
C
L
S
D
S
A
I
F
Honey Bee
Apis mellifera
XP_396816
251
28007
E143
L
G
L
M
L
S
Q
E
A
D
G
V
W
A
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
D263
A
K
I
R
Q
K
I
D
Y
G
L
S
M
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
90.7
94.9
N.A.
93.3
42.5
N.A.
44.3
67.5
51
23.7
N.A.
22.5
29.2
N.A.
38.9
Protein Similarity:
100
99.4
90.9
95.7
N.A.
94.3
54.2
N.A.
49.7
73.1
58
39.9
N.A.
38.9
34.4
N.A.
50.2
P-Site Identity:
100
100
100
93.3
N.A.
100
13.3
N.A.
0
6.6
6.6
26.6
N.A.
13.3
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
33.3
N.A.
13.3
20
26.6
46.6
N.A.
33.3
20
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
0
0
8
8
0
8
0
0
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% D
% Glu:
0
0
54
0
0
0
47
8
0
8
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% F
% Gly:
0
16
0
0
8
0
8
8
16
16
16
0
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
8
0
0
8
16
8
0
8
8
16
0
8
0
% I
% Lys:
0
8
8
0
8
16
8
0
0
0
8
0
0
8
39
% K
% Leu:
8
39
8
0
8
0
0
0
16
0
8
8
8
8
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
8
0
8
0
0
% M
% Asn:
39
8
0
8
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
31
8
0
8
0
0
0
0
0
8
0
0
% Q
% Arg:
16
8
8
16
54
8
8
0
8
39
39
0
47
8
16
% R
% Ser:
8
8
0
8
0
54
0
39
0
16
0
16
8
54
0
% S
% Thr:
8
8
8
8
0
0
0
16
0
0
0
47
0
0
8
% T
% Val:
8
0
8
16
8
0
0
0
47
0
0
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
8
0
0
8
8
0
0
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _